ICMR-Junior Research Fellowships

ICMR JRF Examination is the first step in the process of admission to the Ph.D/ Research Programme through council's support. Test for ICMR JRF fellowship are conducted at the five centres viz. Chandigarh, Chennai, Delhi, Kolkata and Mumbai once a year. The award of JRF is made on merit basis by holding an entrance examination after issuing a countrywide admission notice. The admission notice is published in leading English Newspapers of India usually during March/April and also on the website. The entrance examination is usually held in the first/second week of July.

ICMR holds a national level examination for determining the eligibility of Indian National candidates for the award of Junior Research Fellowships (JRF) through Indian Council of Medical Research. The award of Junior Research Fellowship to the successful eligible candidates will depend on their finding placement in a medical college / hospital / university / national laboratory / institution of higher learning and research as applicable.

A total of 150 Fellowships would be awarded. 120 Fellowships would be awarded for work in the field of biomedical sciences with emphasis on Life Sciences (like microbiology, physiology, molecular biology, genetics, human biology, bioinformatics, biotechnology, biochemistry, biophysics, immunology, zoology, Environment Science, botany, veterinary sciences, bio-informatics etc.). Thirty Fellowships would be awarded for work with emphasis on Social sciences like psychology, sociology, home science, statistics, anthropology and social work.

(I-i) Two separate merit lists, one comprising the candidates qualifying for life sciences and the second for those candidates qualifying for social sciences, will be made on the basis of their performance in the above test.
(I-ii) The candidates selected for the JRF programme of ICMR would be permitted to enroll themselves for the Ph.D. programme of any University recognised by the UGC/MCI. However, the JRF programme would not have any connection with the Ph.D. programme. The validity of fellowship awarded to a candidate will be six months.
Another 100 candidates would be selected for consideration for positions of JRF under various research schemes of ICMR (subject to fulfilling the conditions for appointment under the schemes) for the duration of that scheme. These JRFs would also be permitted to complete Ph.D. while working in the scheme, if enrolled. The validity of result will be two years for placement in ICMR funded projects.
SC/ST/OBC/Physically Handicapped (PH) applicants will be given such special consideration as per policy guidelines.Candidates qualifying for the award of JRF will receive fellowship from ICMR.
Duration and Emoluments:
The existing value of the fellowship is at present Rs. 8000/- (Rupees Eight thousand only) Per month. It will be revised from time to time as decided by the ICMR.

The duration of fellowship will initially be limited till three years carrying a monthly stipend of Rs. 8000/- and an annual contingency grant up to Rs. 7,500/- per annum. The progress of research work would be evaluated annually through annual progress reports. On completion of two years as JRF the stipend of a fellow may be increased to Rs. 9,000/- p.m. for 3rd year on the basis of assessment of candidate's research progress / achievements. Upon such a recommendation, the fellow will be called SRF. In the event of the Committee not recommending upgradation, the fellow will continue as JRF with a stipend of Rs. 8000/- per month for the 3rd year or his/her fellowship may be terminated depending on the decision of the Committee. The duration as SRF may be for a maximum duration of 3 years. Thus, the total tenure as JRF plus SRF shall not exceed 5 (five) years.

The successful candidates would be notified by post and notice published in Employment Newspaper. The list also would be available on the ICMR website. Joining time: Selected candidates must join their respective course on the prescribed date as indicated in their admission letter. The selection of those who fail to join by the specified date shall automatically stand cancelled.

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CSIR- JRF Life Sciences

PAPER I -SECTION A

There is no prescribed syllabus for Paper 1 Section A but the question includes from Computer, Biology, Chemistry, Physics, Mathematics and Geography. Paper 1 Section A contains 30 questions, 5 from each Subject. We are trying to provide syllabus of these subjects that is based on the last 5 year question papers and from the view of some experts.

PAPER I -SECTION B

1. Cell Biology: Structure and function of cells and intracellular organelles (of both prokaryotes and eukaryotes) mechanism of cell division including (mitosis and meiosis) and cell differentiation: Cell-cell interaction: Malignant growth; Immune response: Dosage compensation and mechanism of sex determination.

2. Biochemistry: Structure of atoms, molecules and chemical bonds; Principles of physical chemistry: Thermodynamics, Kinetics, dissociation and association constants; Nucleic acid structure, genetic code, replication, transcription and translation: Structure, function and metabolism of carbohydrates, lipids and proteins; Enzymes and coenzyme; Respiration and photosynthesis.

3. Physiology: Response to stress: Active transport across membranes; Plant and animal hormones: Nutrition (including vitamins); Reproduction in plants, microbes and animals.

4. Genetics: Principles of Mendelian inheritance, chromosome structure and function: Gene Structure and regulation of gene expression: Linkage and genetic mapping; Extrachromosomal inheritance (episomes. mitochondria and chloraplasts); Mutation: DNA damage and repair, chromosome aberration: Transposons; Sex-linked inheritance and genetic disorders; Somatic cell genetics: Genome organisation (in both prokaryotes and eukaryotes).

5. Evolutionary Biology: Origin of life (including aspects of prebiotic environment and molecular evolution); Concepts of evolution: Theories of organic evolution: Mechanisms of speciation; Hardyweinberg genetic equilibrium, genetic polymorphism and selection; Origin and evolution of economically important microbes, plants and animals.

6. Environmental Biology: Concept and dynamics or ecosystem, components, food chain and energy flow, productivity and biogeochemical cycles; Types of ecosystems, Population ecology and biological control: Community structure and organisation: Environmental pollution: Sustainable development; Economic importance of microbes, plants and animals.

7. Biodiversity and Taxonomy: Species concept; Biological nomenclature theories of biological classification, Structural biochemical and molecular systematics: DNA finger printing, numerical taxonomy, Biodiversity, characterization, generation maintenance and loss: Magnitude and distribution of biodiversity, economic value, wildlife biology, conservation strategies, cryopreservation

PAPER II

1. Principles of Taxonomy as applied to the systamics and Classification of Plant Kingdom: Taxonoric structure:
Biosystematics; Plant geography; Floristics.
2. Patterns of variation in morphology and life history in plants: Broad outlines of classification AND evolutionary trends among algae, fungi, bryophytes and pteridophytes; Principles of palaeobotariy; Economic importance of algae, fungi and lichens.
3. Comparative anatomy and developmental morphology of gymnosperms and angiosperms: Histochemical and ultrastructural aspects of development; Differentiation and morphogenesis.
4. Androgensis and gynogenesis; Breeding system; Pollination biology; structural arid functional aspects of pollen and pistil; Male sterility; Self and inter-specific incompatibility Fertilization Embryo and seed development.
5. Plants and civilization; Centres of origin and gene diversity; Botany, utilization, cultivation and improvement of plants of food, drug, fibre and industrial values, Unexploited plants of potential economic value; Plants as a source of renewable energy: Genetic resources and their conservation.
6. Water Relation: Mineral nutrition; Photosynthesis and photorespiration; Nitrogen, Phosphorous and Sulphur metabolism; Stomatal physiology; Source and Sink relationship.
7. Physiology and biochemistry and seed dormancy and germination; Hormonal regulation of growth and development; Photoregulation: Growth responses, Physiology of flowering: Senescence.
8. Principles of plant breeding; important conventional methods of breeding self and cross-pollinated and vegetatively propagated crops: Non conventional methods; Polyploidy: Genetic variability; Plant diseases and defensive mechanisms.
9. Principles of taxonomy as applied to the systematics and classification of the animal kingdom; Classification and interrelationship amongst the major invertebrate phyla; Minor invertebrate phyla, Functional anatomy of the nonchordates; larval forms and their evolutionary significance.
10. Classification and comparative anatomy of protochordates and chordates; Origin, evolution and distribution of chordates groups: Adaptive radiation.
11. Histology of mammalian organ systems, nutrition, digestion and absorption; Circulation (open and closed circular, lymphatic systems, blood composition and function); Muscular contraction and electric organs; Excretion and osmoregulation: Nerve conduction and neurotransmitters; major sense organs and receptors; Homeostatis (neural and hormonal); Bioluminiscence; Reproduction.
12. Gametogenesis in animals: Molecular events during fertilization, Cleavage patterns and fate maps, Concepts of determination, competence and induction, totipotency and nuclear transfer experiments: Cell differentiation and differential gene activity: Morphogenetic determinants in egg cytoplasm; Role of maternal contributions in early embryonic development; Genetic regulations of early embryonic development in Drosophila; Homeotic genes.
13. Feeding, learning, social and sexual behavior of animals; Parental care; Circadian rhythms; Mimicry; Migration of fishes and birds; Sociobiology; Physiological adaptation at high altitude.
14. Important human and veterinary parasites (protozoans and helminths); Life cycle and biology of Plasmodium, Trypanosoma, Ascaris, Wuchereria, Fasciola, Schistosoma and Leishmania; Molecular, cellular and physiological basis of host - parasite interactions.
15. Arthropods and vectors of human diseases (mosquitoes, lice, flies and ticks); Mode of transmission of pathogens by vectors; Chemical, biological and environmental control of anthropoid vectors; Biology and control of chief insect pests of agricultural importance; Plant host-insect interaction, insect pest management; useful insects: Silkworm
16. The law of DNA constancy and C-value paradox; Numerical, and structural changes in chromosomes; Molecular basis of spontaneous and induced mutations and their role in evolution; Environmental mutagenesis and toxicity testing; Population genetics
17. Structure of pro-and eukaryotic cells: membrane structure and function: Intracellular compartments, proteinsorting, secretory and endocytic pathways; Cytoskeleton; Nucleus; Mitochondria and chloroplasts and their genetic organisation; cell cycle; Structure and organisation of chromatin, polytene and lampbrush chromosomes; Dosage compensation and sex determination and sex-linked inheritance.
18. Interactions between environment and biota: Concept of habitat and ecological niches; Limiting factor; Energy flow, food chain, food web and tropic levels; Ecological pyramids and recycling, biotic community-concept, structure, dominance, fluctuation and succession; N.P.C. and S cycles in nature.
19. Ecosystem dynamics and management; Stability and complexity of ecosystems; Speciation and extinctions; environmental impact assessment; Principles of conservation; Conservation strategies; sustainable development.
20. Physico-chemical properties of water; Kinds of aquatic habitats (fresh water and marine); Distribution of and impact of environmental factors on the aquatic biota; Productivity, mineral cycles and biodegradation in different aquatic ecosystems; Fish and Fisheries of India with respect to the management of estuarine, coastal water systems and man-made reservoirs; Biology and ecology of reservoirs.
21. Structure, classification, genetics, reproduction and physiology of bacteria and viruses (of bacteria, plants and animals); Mycoplasma protozoa and yeast (a general accounts).
22. Microbial fermentation; Antibiotics, organic acids and vitamins; Microbes in decomposition and recycling processes; Symbiotic and asymbiotic N2-fixation; Microbiology of water, air, soil and sewage: Microbes as pathological agents in plants, animals and man; General design and applications of a biofermenter, Biofertilizer.
23. Antigen; Structure and functions of different clauses of immunoglobulins; Primary and secondary immune response; Lymphocytes and accessory cells; Humoral and cell mediated immunity; MHC; Mechanism of immune response and generation of immunological diversity; Genetic control of immune response, Effector mechanisms; Applications of immunological techniques.
24. Enzyme Kinetics (negative and positive cooperativity); Regulation of enzymatic activity; Active sites; Coenzymes Activators and inhibitors, isoenzymes, allosteric enzymes; Ribozyme and abzyme.
25. Van der Waalls, electrostatic, hydrogen bonding and hydrophobic interaction; Primary structure and proteins and nucleic acids; Conformation of proteins and polypeptides (secondary, Tertiary, quaternary and domain structure); Reverse turns and Ramachandran plot; Structural polymorphism of DNA, RNA and three dimensional structure of tRNA; Structure of carbohydrates, polysaccharides, glycoproteins and peptido-glycans; Helixcoil transition; Energy terms in biopolymer conformational calculation.
26. Glycolysis and TCA cycle; Glycogen breakdown and synthesis; Gluconeogenesis; Interconversion of hexoses and pentoses; Amino acid metabolism; Coordinated control of metabolism; Biosynthesis of purines and pyrimidines; Oxidation of lipids; Biosynthesis of fatty acids; Triglycerides; Phospholipids; Sterols.
27. Energy metabolism (concept of free energy); Thermodynamic principles in biology; Energy rich bonds; Weak interactions; Coupled reactions and oxidative phosphorylations; Group transfer Biological energy transducers; Bioenergietics.
28. Fine structure of gene, Eukaryotic genome organisation (structure of chromatin, coding and non-coding sequences, satellite DNA); DNA damage and repair, DNA replication, amplification and rearrangements.
29. Organization of transcriptional units; Mechanism of transcription of prokaryotes and eukaryotes; RNA processing (capping. polyadenylation, splicing, introns and exons); Ribonucleoproteins, structure of mRNA; Genetic code and protein synthesis.
30. Regulation of gene expression in pro and eukaryotes; Attenuation and antitermination; Operon concept; DNA methylation: Heterochromatization; Transposition; Regulatory sequences and transacting factors; Environmental regulation of gene expression.
31. Biochemistry and molecular biology of cancer; Oncogenes; Chemical carcinogenesis; Genetic and metabolic disorders; Hormonal imbalances; Drug metabolism and detoxification; Genetic load and genetic counseling.
32. Lysogeny and lytic cycle in bacteriophages; Bacterial transformation; Host cell restriction; Transduction; Complementation; Molecular recombination; DNA ligases; Topoisomerases; Gyrases; Methylases; Nucleases;
Restriction enctonucleases; Plasmids and bacteriophage base vectors for cDNA and genomic libraries.
33. Principles and methods of genetic engineering and Gene targeting; Applications in agriculture, health and industry.
34. Cell and tissue culture in plants and animals; Primary culture; Cell line; Cell clones; Callus cultures; Somaclonal variation; Micropropagation; Somatic embryogenesis; Haploidy; Protoplast fusion and somatic hybridization; Cybrides; Genetransfer methods in plants and in animals; Transgenic biology; Allopheny; Artificial seeds; Hybridoma technology.
35. Structure and organisation of membranes; Glycoconjugates and proteins in membrane systems; Ion transport, Na+IK+ATPase; Molecular basis of signal transduction in bacteria, plants and animals; Model membranes; Liposomes.
36. Principles and application of light phase contrast, fluorescence, scanning and transmission electron microscopy, Cytophotometry and flow cytometry, fixation and staining.
37. Principles and applications of gel-filtration, ion-exchange and affinity chromatography; Thin layer and gas chromatography; High pressure liquid (HPLC) chromatography; Electrophoresis and electrofocussing; Ultracentrifugation (velocity and buoyant density).
38. Principles and techniques of nucleic acid hybridization and Cot curves; Sequencing of Proteins and nucleic acids; Southern, Northern and South-Western blotting techniques; Polymerase chain reaction; Methods for measuring nucleic acid and protein interactions.
39. Principles of biophysical methods used for analysis of biopolymer structure, X-ray diffraction, fluorescence, UV, ORD/CD, Visible. NMA and ESA spectroscopy: Hydrodynamic methods: Atomic absorption and plasma emission spectroscopy.
40. Principles and applications of tracer techniques in biology; Radiation dosimetry: Radioactive isotopes and half life of isotopes; Effect of radiation on biological system: Autoradiography; Cerenkov radiation; Liquid scintillation spectrometry.
41. Principles and practice of statistical methods in biological research, samples and populations; Basic statistics average, statistics of dispersion. Coefficient of variation: Standard error; Confidence limits: Probability distributions (biomial, Poisson and normal); Tests of statistical significance: Simple correlation of regression; Analysis of variance.